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This is one of the most densely glycosylated molecules known and the density is sufficiently high to prevent the normal maturation process of glycans during biogenesis in the endoplasmic and Golgi apparatus.The unusual processing and high density means that almost all broadly neutralising antibodies that have so far been identified (from a subset of patients that have been infected for many months to years) bind to or, are adapted to cope with, these envelope glycans.
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Over half of the mass of the trimeric envelope spike is N-linked glycans.
The density is high as the glycans shield the underlying viral protein from neutralisation by antibodies.
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